Cancer is a group of diseases characterized by autonomous, uncontrolled cell growth and proliferation and has become one of the leading causes of morbidity and mortality worldwide. Cancer cells are allowed to grow and divide, invade or spread to other parts of the body out of control by changes to genes. Many common types of cancer including lung cancer, colon cancer, rectum cancer, stomach cancer, liver cancer do a great harm to human health. Systematically studying these malignant diseases can help us find therapeutic strategies to inhibit cancer progression.
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Immunology covers the study of all aspects of the immune system. As an important branch of the medical and biological sciences, immunology focuses on the structure and function of cellular components in the immune system, the characteristics of immune responses, the mechanisms of host defense against pathogens. The immune system protects the body against attacks by “foreign” invaders. The fundamental defects in the immune system can result in human diseases, such as autoimmune diseases, inflammatory diseases, and cancer.
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Neuroscience is the study of the nervous system, which refers to wide ranging areas of ion channels, synaptic transmission, neural development, sensory and cognitive physiology and neural circuits. Research in development, homeostasis, and dysfunction of nervous system, permits a detailed understanding of neurological diseases such as Alzheimer's and Parkinson's diseases. Systematically studying on these malignant diseases will provide insights into the exciting world of the brain, spinal cord, neurons and the senses.
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Stem cells are a class of undifferentiated cells. They possess the ability of long-term self-renewal and can differentiate into specialized cells. Embryonic stem cells and adult stem cells make up the two main types of stem cells in mammals. Both types of stem cells have the same capacity to differentiate into different cell types, such as blood, heart, bones, skin, muscles, brain etc. Their ability of stimulating the body to repair itself make them be used to treat disease and injury.
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Microbiology is the study of microbes which are invisible to the eye, it covers a wide range of problems in the areas of medicine, agriculture, bioremediation and food industries. Microbes including viruses, bacteria, fungi, slime molds and protozoa. Some of microbes are sometimes responsible for diseases, others are beneficial for keeping balance of ecosystem. Microbes are also bound together with many important biological processes such as immune responses.
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Cell biology is a branch of biology based on the concept of the cell as the fundamental unit of life. It applies the basic laws of chemistry and physics to living things. Research in structures and functions of the cells, permits a detailed understanding of biological processes such as signaling pathways, life cycle, molecular transportation, and interactions with their environment.
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Cardiovascular diseases (CVDs) as the leading cause of death worldwide involve the disorders of the heart and blood vessels. Investigation into the cardiovascular system will help scientists better understand the underlying mechanisms during diseases development. A lot of studies will be required to create effective treatments against cardiovascular diseases (CVDs).
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Metabolism is a collection of chemical reactions catalyzed by enzymes in the living state of the cells and the organism. It converts the fuel in the biochemicals into the energy to run cellular processes, resulting in achievement of the material exchange, self-renewal as well as the relative stability of the internal environment. Metabolism disorder can lead to diseases including obesity, diabetes, lipidemia, hepatic lipidosis, and so on.
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Signal transduction, also known as cell signaling, is the transmission of molecular signals from a cell's exterior to its interior. Signal transduction is responsible for many processes such as cell growth, proliferation, healing, differentiation, metabolism and communication. Signal transduction pathways is the process by which a physical or chemical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response. The intracellular signaling transduction is highly receptor specific, thereby maintaining the specificity of the incoming signal inside the cell. Signal transduction pathways amplify the incoming signal by a signaling cascade using a network of enzymes that act on one another in specific ways to ultimately generate a precise and appropriate physiological response by the cell.
A ligand-gated ion channel, upon binding with a ligand, changes conformation to open a channel in the cell membrane through which ions relaying signals can pass. An example of this mechanism is found in the receiving cell of a neural synapse. The influx of ions that occurs in response to the opening of these channels induces action potentials, such as those that travel along nerves, by depolarizing the membrane of post-synaptic cells, resulting in the opening of voltage-gated ion channels.
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Developmental biology refers to the process of growth and development in animals and plants, it also involves in regeneration, asexual reproduction, metamorphosis and the differentiation of stem cells. Developmental biology encompasses the biology that studies the formation of pattern in development, and mechanisms of the morphogenesis of tissues, organs and organisms. Systematically studying on the process of developmental biology will help us understand developmental abnormalities.
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Epigenetics refers to changes in a chromosome such as DNA methylation and histone modification that affect transcriptional activation and repression, DNA repair, DNA recombination, DNA replication, and chromosome segregation.
Many key proteins such as protein kinases and phosphatases, protein acetyltransferases and deacetylases, protein methyltransferases and demethylases are involved in the regulation of nuclear signaling.
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Tags, also called antigen epitopes and antigen determinant, refer to the special region or group of antigen molecules that determine the specificity of antigen, and the structure or sequence that specifically combines with antibody. The fusion protein containing the target gene and epitope label was constructed with DNA recombination technique, and then the fusion protein was identified and purified by specific tag antibody. Tag antibodies can be highly specific combined with the corresponding tag fusion protein, which are common tools for researches in gene protein expression, signal transduction and gene function.
Cell markers, also known as cell surface antigens, can be used as cell surface antigens for identification and classification of cells. The majority of cell markers are molecules or antigens on the surface of cell membranes. Unique to different cell types, there exist specific markers or antigens, which not only act as markers for specific cells, but also play key functional roles. It is possible to diagnose diseases or direct treatment by identifying the presence of these specific markers.
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